The Billings Gazette
Billings, Montana
Tuesday Morning, July 10, 1956
New Female Sex Hormone Aids In Saving Premature
Babies
NEW YORK (AP) -- A new female sex hormone promises
to save thousands of babies who now are born prematurely, a drug
firm said Monday.
It can work in either of two ways to save babies who are born too
soon from premature labor. It sometimes stops the premature
labor contractions, thus giving the infant more time to develop in
the womb.
Or it can make the premature birth easier so the babies are not
fatally injured before being born.
The hormone is Relaxin, a natural sex hormone playing a vital role
in the birth process. Warner-Chilcott Laboratories of New York
announced success in making supplies available for the first time,
under the name Releasin, to help reduce the loss of life from
premature labor.
In normal pregnancy, Relaxin stretches pelvic ligaments and softens
tissues of the womb and birth canal at the time of delivery.
It also makes labor contractions less severe. Lack of Relaxin
is believed responsible for premature labor and stillbirths.
In many cases of premature labor, there are strong contractions but
the birth canal is not ready and the baby is fatally injured.
In some cases when the hormone halted the labor, the normal delivery
later on was quick and nearly painless, said Dr. George H. Mangun,
director of research of the laboratories.
In clinical trials, Relaxin was credited with saving seven out of 10
babies who otherwise probably would have been stillborn.
The hormone drug is still scarce, and expensive. Costs of
treating one case in a hospital are estimated at from $150 to $175.
Some 200,000 babies are stillborn each year from premature labor.
At present there will be enough Relaxin to treat only some 18,000
women annually, but this could mean saving 12,000 to 14,000 infants,
Dr. Mangun said.
The hormone is obtained from the ovaries of pregnant sows, involving
elaborate work to separate out purified Relaxin. From 500
sows, only enough is obtained to treat 6 to 8 women. More
efficient sources of supply are being sought.
The hormone appears most effective when given to women threatened
with premature labor in the 29th to 32nd weeks or pregnancy.
In time, when supplies increase, it might be used to induce delivery
at desired times, and possibly make birth easier.
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